Levemir from the famous Novo Nordisk manufacturer is a modern brand of a long-acting insulin analog, which is used to meet the need for basal insulin. On Insulin.Store website, you can find Levemir in 2 basic forms of release:
Levemir is intended for the treatment of type 1 and type 2 diabetes mellitus in adults and children. It can be combined with both short-acting insulin and oral hypoglycemic agents.
You can buy authentic Levemir insulin products on Insulin.Store at the most beneficial prices. Please note that you will have to provide a valid medical prescription for the medication from your doctor before you place an order.
Levemir is a soluble analog of basal insulin with a prolonged profile of action, which is used as basal insulin. The hypoglycemic effect of the drug is to promote the uptake of glucose by tissues after binding of insulin to the receptors of muscle and fat cells, as well as the simultaneous inhibition of glucose secretion from the liver. The duration of action of Levemir is statistically significantly less variable than that of the neutral protamine Hagedorn (NPH-insulin). Levemir is released gradually and therefore causes less dramatic changes in blood glucose levels compared to conventional long-acting NPH insulins. The prolonged action of the drug is due to the close relationship of insulin detemir molecules at the injection site and the attachment of albumin to them through the side chain of fatty acids. Compared with NPH insulin, insulin detemir is more slowly distributed in peripheral target tissues. This combined mechanism of prolongation of action causes a more predictable absorption and action profile of the drug Levemir FlexPen than NPH insulin.
In combination with such agents, the initial dose of Levemir® is 10 U or 0.1–0.2 U / kg. The dose selection is carried out according to the needs of the patient. The drug should be administered 1 time per day in the evening, during dinner, or before bedtime. The duration of its action is up to 24 hours. The pre-filled syringe-pen Levemir Flexpen provides easy administration of the drug.
The effect of the drug lasts up to 24 hours depending on the dose, which allows you to be limited to one or two injections per day. When administered twice daily, glycemic stabilization can be achieved after 2-3 injections. When Levemir Flextouch is administered at a rate of 0.2-0.4 IU / kg body weight, more than 50% of the maximum effect is achieved within 3-4 hours and lasts approximately 14 hours after injection. After subcutaneous administration of the drug, the pharmacological effect (maximum effect, duration of action, total effect) is proportional to the dose of the drug.
In long-term clinical trials, Levemir Flextouch provided smaller daily fluctuations in fasting glucose compared to NPH insulin. According to studies in patients with type 2 diabetes who used basal insulin in combination with oral hypoglycemic agents, the effectiveness of glycemic control (HbA1C) with Levemir Flextouch is comparable to that of insulin NPH and insulin.
Levemir Flextouchis a soluble analog of basal insulin with prolonged action (up to 24 hours). Compared to other insulin preparations, basal-bolus therapy with Levemir Flextouch does not cause weight gain. Reducing the risk of nocturnal hypoglycemia compared to NPH-insulin allows for more intensive titration to achieve target blood glucose levels as part of basal-bolus therapy. Levemir Flextouch provides better glycemic control by fasting plasma glucose compared to NPH insulin. Levemir Flextouch can be used alone as basal insulin or in combination with a bolus insulin. The drug can also be used with oral hypoglycemic agents and/or agonists of GPP-1 receptors. In combination with oral hypoglycemic agents or when GPP-1 receptor agonists are added to adult patients, it is recommended to start treatment with Levemir Flextouch at 0.1–0.2 units/kg body weight or 10 units once daily. The dose of the drug should be selected depending on the needs of the patient. When adding GPP-1 receptor agonists to Levemir Flextouch, it is recommended to reduce the dose of the drug by 20% to reduce the risk of hypoglycemia. Subsequently, the dose should be adjusted to the needs of the patient.
Pregnancy, breastfeeding, other medical conditions, as well as changes in the diet, physical activity, and lifestyle may also impact your need for insulin. Inform your doctor about any changes in your health or lifestyle to adjust the dosage of Levemir correspondingly.
Adverse reactions observed in patients receiving Levemir are manifestations of the pharmacological action of insulin. The overall expected incidence of adverse reactions in patients using this drug is 12%. The most common side effect of insulin therapy is hypoglycemia (low blood sugar).
Clinical studies have shown that cases of severe hypoglycemia requiring care from others occur in approximately 6% of patients receiving Levemir FlexPen.
Reactions at the injection site of Levemir are slightly more common than with human insulin. These reactions include pain, redness, hives, inflammation, bruising, swelling, and itching at the injection site. They usually pass fairly quickly within a few days or weeks with continued treatment. Refractive errors and edema may occur at the beginning of insulin administration; usually, these reactions are temporary. Rapid improvement in blood glucose control can lead to a state of “acute pain neuropathy,” which is usually reversible. A sharp improvement in glycemic control due to intensification of insulin therapy may be accompanied by a temporary exacerbation of diabetic retinopathy, while long-term, well-established glycemic control reduces the risk of progression of diabetic retinopathy.
The syringe handle with Levemir Flextouch or PenFill should be stored in the original package. Before use: store in the refrigerator (at a temperature of 2-8 ° C), not too close to the freezer. Do not freeze. Protect from light.
When using a syringe pen or when the syringe pen is worn as a spare: store at a temperature not exceeding 30 ° C. Can be stored in the refrigerator (at a temperature of 2-8 ° C). Use within 6 weeks. Do not freeze. To protect from light, keep the syringe handle with the cap closed when not in use. Keep out of reach of children.
Never use insulin after the expiry date, which is stated on the pack.
Any insulin-based medication, according to the rules, requires offline or online pharmacy store representatives to ask for a prescription. When buying Levemir from Insulin.Store, you will need to attach a valid prescription from the doctor for the insulin product even if you buy it for your pet. We will be able to proceed with your order just upon successful verification of your prescription. In the opposite case, we will have to either ask you to provide a valid prescription or cancel your order.
When your prescription expires, you will also have to attach a new prescription from your doctor. Read the ‘How to order’ page for more information.
Please be careful and do not buy any insulin medications from places that do not ask for a prescription. It may be dangerous to your health and life.
Insulin Store is doing its best to make the prices for insulin products one of the most beneficial on the market. Here are the current prices for Levemir insulin products on our website Insulin.Store:
Please note that the prices may vary. You may check the valid prices by visiting the website Insulin.Store or contacting our sales managers, who are always here to help you out!
Buying Levemir insulin from Canada is not just possible but also very beneficial. Insulin Store is a Canadian pharmaceutical company that distributes insulin, insulin-like medications, and dietary supplements for adults, children, and their pets with type 1 diabetes and type 2 diabetes mellitus for 6 years. Now, we ship to the United States as well. This is how our company benefits our customers:
To learn the rules of how to buy medications online on our website, you can visit the ‘How to order’ page. Please be aware that providing a valid prescription for the drug from your health care provider is a compulsory step of cooperating with our company. Your prescription will be further verified by our moderators, and just upon its successful verification, you will be able to conduct a purchase on our website Insulin.Store. We do not sell insulin medication to patients without valid prescriptions!
If you have any questions left concerning the product, prices, discounts, shipping, or service, you are free to ask them our team, and we will be glad to help you out!