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Saxenda vs. Mounjaro: Uncover Weight Loss Medications

by Owen Clarke 11 Jan 2024

Have you ever thought about body weight reduction? This concern has disturbed almost everyone. Pharmaceutical advancements have introduced a plethora of new weight-loss medications, providing us with different programs to reduce weight. This is particularly promising for those combatting obesity or aiming to lose weight. Mounjaro and Saxenda are innovative products designed to reduce blood sugar levels and promote significant weight loss.

Struggling to decide on the ideal weight-loss medication? In this article, we’ll provide comprehensive insights into Saxenda and Mounjaro and help to determine which drug aligns better with your goals.

Before we start, enjoy the convenience of our website to order Saxenda. We make insulin and other treatments affordable. Feel free to seek a complimentary professional consultation. A valid prescription from your doctor is required for any purchase at our online store.

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Saxenda and Mounjaro Overview

Saxenda belongs to the class of incretin mimetic. It is manufactured by Novo Nordisk (Denmark). Saxenda utilizes liraglutide as its active ingredient, a potent GLP-1 receptor agonist. Originally introduced for type 2 diabetes under the brand name Victoza.

Liraglutide demonstrated remarkable effects on body weight reduction during clinical studies. This prompted Novo Nordisk to develop Saxenda specifically to address overweight and obesity concerns. Saxenda has become widely recognized since being FDA-approved in 2014.

Mounjaro is developed by Eli Lilly (USA). Its active ingredient is tirzepatide. This component sets Mounjaro as a dual receptor agonist, activating both GLP-1 and GIP.

Unlike many medications in its class, Mounjaro is not solely a GLP-1 receptor agonist, but also a glucose-dependent insulinotropic polypeptide (GIP) mimetic. This unique dual action supports blood glucose control and aids in storing more excess energy. While currently approved for type 2 diabetes in the U.S., Mounjaro is waiting for FDA approval as a weight loss medication.

Injectable Weight Loss Medications

Mounjaro and Saxenda are administered for diabetes type 2, but there was found additional positive effect — weight loss. These medications mimic the action of glucagon-like peptide-1 (GLP-1), a natural hormone in the body. The mechanisms of action for these injectable medications involve key processes:

  • GLP-1 receptor activation in the pancreas and the gastrointestinal tract helps with metabolic processes.
  • Increased insulin secretion regulates blood sugar levels and improves glucose control.
  • Appetite suppression reduces food intake.
  • Slowing gastric emptying leads to a feeling of fullness and increased satisfaction after meals.
  • Enhanced fat metabolism helps to utilize the stored fat for energy. This effect contributes to weight loss by promoting the breakdown of fat stores.
  • Balanced blood sugar control is achieved through the combined effects of insulin secretion and glucose metabolism. Improved blood glucose levels are supporting weight loss.

Mounjaro and Saxenda share the general mechanism of action exhibited by the agonistizing GLP-1 receptor. There are nuanced differences in their specific actions and effects due to variations in their active ingredients and dual agonist properties.

Additionally, the injectable nature of these weight-loss drugs ensures a controlled and sustained release of metabolic hormones, optimizing their therapeutic effects for weight management.

Clinical Trials and Possible Results

Mounjaro showcases more substantial results in the clinical trials. Mounjaro’s level of weight loss compared to Saxenda ones is notably higher. Participants, who administered Mounjaro, experienced an impressive average reduction in body weight of up to 21%. The figure shows higher results than the 6.4% average weight loss observed with Saxenda. This stark contrast highlights Mounjaro’s potential for fostering more significant weight loss outcomes, a crucial factor in addressing concerns related to high blood pressure and weight-related comorbidities.

When delving into the specifics, it becomes evident that Mounjaro’s efficacy is dose-dependent, according to studies examining different dosage levels. Individuals who took the highest 15 mg dose of Mounjaro exhibited an impressive weight reduction of nearly 21% within approximately a year and a half. This is notably higher than the 19.5% and 15% body weight loss observed in those taking 10 mg and 5 mg dosages, respectively.

Ideal Candidates for Saxenda and Mounjaro Treatment

Mounjaro is designed for adults aged 18 and older diagnosed with type 2 diabetes. It received FDA approval for diabetes treatment in 2022. Anticipated to attain FDA approval as an anti-obesity medication by the end of 2023, Mounjaro is currently available for off-label prescription by healthcare providers for weight loss management.

In contrast, Saxenda stands among the FDA-approved medications for addressing obesity and excess weight. The eligibility for Saxenda use in body weight reduction includes:

  • Obese individuals with a body mass index (BMI) of 30 or higher.
  • Overweight individuals with a BMI of 27 or higher, coupled with a weight-related health condition
  • For adolescents, the patient must be classified as obese, weighing at least 130 pounds (≈60 kilograms)

You may consider Saxenda and Mounjaro for treatment if you are looking for medicine to promote weight loss and maintain weight control, reduce high blood sugar levels, and balance insulin resistance.

You should avoid Mounjaro and Saxenda if you:

  • pregnant or breastfeeding at this period;
  • have uncontrolled hypertension;
  • experience cardiovascular issues;
  • have a history of gallbladder disease;
  • allergic or hypersensitive to the components of these medications.

Saxenda and Mounjaro are well-suited for supporting weight loss, blood sugar control, and balancing insulin release.

Dosage of Weight Loss Drugs

When taking Mounjaro and Saxenda, understanding the dosage protocols is crucial. The initial dose is carefully determined by the healthcare provider according to your health condition.

Mounjaro’s treatment is based on a once-weekly injection and offers convenient dosing schedules. Saxenda follows a daily dosing protocol, requiring an injection once per day.

The dosage of these weight medications may be adjusted based on individual response and tolerance. Healthcare providers may tailor the dosage to optimize weight loss outcomes. Treatment often involves a gradual increase in dosage to enhance tolerance and mitigate potential adverse reactions.

Healthcare providers closely monitor individuals undergoing treatment with Mounjaro or Saxenda. Regular check-ins, adjustments in dosage if necessary, and continuous assessment of progress contribute to a comprehensive and personalized loss plan.

Side Effects after Injections

As individuals explore the potential benefits of a weight loss drug, it’s imperative to understand the associated side effects for informed decision-making and proactive healthcare management.

Comparing Mounjaro vs. Saxenda, they share common side effects. Gastrointestinal discomfort, characterized by nausea and changes in appetite, is frequently reported. These effects are transient and tend to diminish as the body acclimates to the medication.

Also, Mounjaro and Saxenda may cause lower blood sugar levels (hypoglycemia). Individuals should be attuned to potential symptoms of low blood sugar and collaborate closely with healthcare to maintain blood sugar control.

Individuals using Mounjaro may experience alterations in fasting plasma glucose, requiring careful monitoring, particularly for those managing diabetes. Additionally, the dual action may contribute to nuanced responses.

Saxenda, administered through a once-daily subcutaneous injection, carries its own set of potential side effects, such as changes in appetite and digestion.

Ongoing collaboration with healthcare providers ensures a proactive and supportive approach to managing potential side effects while working towards achieving the desired weight loss outcomes.

Lifestyle Changes

Both medications are prescribed alongside lifestyle modifications, including a balanced diet and regular exercise for optimal results and to mitigate risk factors. Lifestyle adjustments play a synergistic role in maximizing the benefits of Saxenda and Mounjaro. Here are key aspects of lifestyle modifications:

  • a healthy diet and mindful eating practices;
  • regular exercise routine;
  • blood glucose levels monitoring;
  • hydration and self-care;
  • patient education and adherence to prescribed treatment plans.

Most recommendation of doctors emphasizes fostering sustainable habits that promote overall health and weight reduction.

Mounjaro vs. Saxenda: Main Differences and Similarities

Understanding the distinctions and parallels between Mounjaro and Saxenda is crucial. Both medications belong to one class, yet they possess unique characteristics that set them apart.

Their similar features are:

  • mechanism of action;
  • weight loss goals;
  • lowering blood sugar levels.

The main differences are:

  • dual receptor agonism (Mounjaro);
  • once-weekly vs. once-daily injection;
  • active ingredients;
  • FDA approval status for weight management;
  • glucose-dependent insulinotropic polypeptide mimetic (Mounjaro).

The choice between the two often hinges on individual preferences, lifestyle considerations, and healthcare provider recommendations based on specific health needs and goals.

SIDE NOTE: Are you curious about Saxenda’s timeline for effectiveness and considering it for weight loss? Explore our article, “How Long Does It Take Saxenda to Work?” for valuable insights into the duration it takes for Saxenda to show results, providing information to help you make informed decisions on your weight loss journey.


You may search for other weight-loss medications, but it is better to be well informed. Hopefully, this exploration helped you uncover all the details about medication to lose weight. Mounjaro stands out with weekly injections, doubled benefits, and unique ingredients. Saxenda has daily injections and is FDA-approved for obesity. Both work best with balanced diets and exercise. Choose the right fit for your weight management with the guidance of your healthcare provider.

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